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PubMed

Borrowing from the cancer playbook: a master protocol basket trial for hard-to-heal wound therapeutics targeting shared pathobiology.

PMID: 42397807 ·

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RevistaJournal of wound care
Ano
PMID42397807

Resumo

Hard-to-heal wounds, such as diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs), remain associated with poor healing outcomes despite optimised standard care. Although classified by aetiology, these wounds share common pathophysiological features that may be amenable to mechanism-targeted therapies. This manuscript aims to describe the design, scientific rationale and statistical framework of a mechanism-driven basket trial evaluating wound therapies across multiple wound aetiologies. This

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