Systematic review of outcomes and endpoints in acute migraine clinical trials.

Abstract

To review the acute migraine clinical trial literature and provide a summary of the endpoints and outcomes used in such trials. A systematic literature review, following a prespecified (but unregistered) protocol developed to adhere to recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, was conducted to understand endpoints and outcomes used in acute migraine clinical trials. Predefined terms were searched in PubMed to locate clinical trials assessing acute