Monocyte activation test (MAT) as an ethical alternative to animal testing.

Abstract

Ethical considerations surrounding the utilization of animals in scientific research have prompted a widespread search for alternative methodologies. This review explores the historical context and ethical dilemmas associated with traditional animal testing methods, before introducing the Monocyte Activation Test (MAT) as a promising alternative, and outlining its basic principles, historical development, and advantages over conventional animal testing. The role of monocytes in the immune system