VASN drives gastric tumorigenesis via activation of the COL4A1/PI3K/AKT axis during Helicobacter pylori infection.

Abstract

Vasorin (VASN) is linked to tumor progression in various cancers, its role and regulatory mechanisms in gastric cancer (GC) are still unknown. Human gastric mucosal samples, VASN heterozygous-deficient (VASN Elevated VASN expression was significantly associated with poor clinical outcomes in GC patients. We identified a strong correlation between increased VASN expression, driven by Helicobacter pylori (H. pylori) infection, and the progression of gastric carcinogenesis. Functional studies demon