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PubMed

Comparative Effectiveness Research Using Randomized Trials and Observational Studies: Validity and Feasibility Considerations.

PMID: 40719151 · 2026

JournalThrombosis and haemostasis
Year2026
PMID40719151

Abstract

In comparative effectiveness research (CER), ensuring internal, construct, and external validity is crucial. Internal validity determines whether observed outcomes are causally linked to an intervention; construct validity assesses whether a study measures what it intends to; and external validity relates to generalizability in routine practice. Double-blind randomized trials optimize internal validity by minimizing bias and confounding, while construct validity is strengthened through pre-speci

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