Mining and evaluation of security alert signals of neuroprotective agents based on the Jinan adverse event reporting system database: a retrospective study.

Abstract

Pharmacologic agents with proposed neuroprotective properties are increasingly investigated; however, limited regulation and heterogeneous evidence raise concerns about their safety profiles. To establish a foundation for its safe clinical use, the data mining technology was used to investigate the safety warning signals of neuroprotective agent post-market approval. The Jinan adverse event (AE) reporting system database was searched for AEs related to neuroprotective agents from January 2000 to