Definition of critical skin defect and concepts of structural and functional repairs: Proposal and verification in a rat model.

Abstract

Rats are often used to prepare skin defect models. However, the skin defect sizes of the models prepared by researchers are different, and the lack of consensus on the critical-size defect makes it difficult to compare their research results. The time for wound closure was evaluated and recorded through gross observation. The regression equation between the healing time and the diameter of skin defect was established, which can be used to predict the healing time for a certain skin defect size i