CRMIPred: Identifying the spatial interactions among cis-regulatory modules via considering their cross-attended epigenetic profiles.

Abstract

Modular DNA elements known as cis-regulatory modules (CRMs) play central roles in transcriptional regulation in metazoan species. Beyond their individual functions, CRMs can physically interact with one another to cooperatively regulate target gene expression, forming an additional layer of transcription regulation. Experimental identification of such interactions typically relies on chromosome conformation capture technologies coupled with sequencing (HiC), which require high sequencing depths