Targeting Cellulite as a Metabolic-Dermal Interface: Effects of Tirzepatide and a Multi-Pathway Topical Therapy (G21) in a 12-Month Observational Study.

Abstract

Background Cellulite is a highly prevalent condition associated with alterations in adipose tissue architecture, microcirculation, and connective tissue integrity. Emerging evidence suggests that cellulite may represent a manifestation of both local structural changes and systemic metabolic dysfunction. This study aimed to evaluate the independent and combined effects of systemic metabolic therapy with tirzepatide and a multi-target topical formulation (G21) on cellulite severity and body compos