Disclaimer: This site aggregates publicly available data from official government sources (FDA, ClinicalTrials.gov, PubMed, SEC EDGAR) for general reference only. It does NOT constitute medical advice, diagnosis, treatment recommendations, or investment advice.

Clinical Trial

Individualized (fMRI-guided) TMS Intervention for PTSD

NCT: NCT07785908 · NOT_YET_RECRUITING

NCT IDNCT07785908
StatusNOT_YET_RECRUITING
Start Date2026-10-12
Completion2028-08
SponsorUniversity of Pennsylvania (OTHER)
First posted
Last updated

Brief Summary

The goal of this clinical trial is to learn how transcranial magnetic stimulation (TMS) affects brain circuits involving the amygdala in adults with posttraumatic stress disorder (PTSD). The main questions it aims to answer are: * Can MRI-guided TMS engage the amygdala by stimulating an individualized brain target connected to the amygdala? * Does stimulation of this individualized target engage the amygdala differently than stimulation of control sites? * Does a 6-week course of active TMS, compared with sham TMS, change amygdala responses and physiological responses to fear? Researchers will compare active TMS with sham TMS to evaluate changes in the targeted brain circuit and fear-related responses. Participants will: * Receive active or sham TMS every weekday for 6 weeks * Undergo MRI scans with TMS before and after the 6-week intervention to measure brain responses to stimulation * Participate in fear learning and memory tasks while physiological responses are measured * Undergo additional MRI scans, clinical assessments, questionnaires, and cognitive testing * Complete remote follow-up assessments at 1, 6, and 12 months after the intervention

Frequently Asked Questions

What is Individualized (fMRI-guided) TMS Intervention for PTSD?

Individualized (fMRI-guided) TMS Intervention for PTSD is a clinical trial registered under NCT07785908. Current status: NOT_YET_RECRUITING.

What is the status of NCT07785908?

The current status of NCT07785908 (Individualized (fMRI-guided) TMS Intervention for PTSD) is: NOT_YET_RECRUITING.

When did Individualized (fMRI-guided) TMS Intervention for PTSD start?

Individualized (fMRI-guided) TMS Intervention for PTSD started on 2026-10-12.

Official Source

View on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov API. For the most current status, refer to the official record.