A Prospective Study of Cold Exposure in Patients With MASH
NCT: NCT07821749 · ACTIVE_NOT_RECRUITING
Brief Summary
This prospective, single-center, single-arm exploratory study aims to evaluate the safety, feasibility, and potential metabolic and hepatic effects of repeated cold exposure in patients with metabolic dysfunction-associated steatohepatitis (MASH). A total of 11 participants with MASH will undergo cold exposure using a water-perfused cooling suit once daily for approximately 120 minutes over a 3-month intervention period. Liver fat content, liver function, lipid metabolism, body weight, and body mass index will be assessed before and after the intervention. Liver fat content will be evaluated by magnetic resonance imaging proton density fat fraction (MRI-PDFF), and blood tests will include alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), and total cholesterol (TC). Liver ultrasound or liver stiffness-related measures and noninvasive fibrosis scores will also be evaluated when available. Safety, tolerability, adherence, and cold-related adverse events will be monitored throughout the study.
Frequently Asked Questions
What is A Prospective Study of Cold Exposure in Patients With MASH?
A Prospective Study of Cold Exposure in Patients With MASH is a clinical trial registered under NCT07821749. Current status: ACTIVE_NOT_RECRUITING.
What is the status of NCT07821749?
The current status of NCT07821749 (A Prospective Study of Cold Exposure in Patients With MASH) is: ACTIVE_NOT_RECRUITING.
When did A Prospective Study of Cold Exposure in Patients With MASH start?
A Prospective Study of Cold Exposure in Patients With MASH started on 2026-07-08.
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Official Source
View on ClinicalTrials.gov →Data sourced from ClinicalTrials.gov API. For the most current status, refer to the official record.