Fractional CO₂ Laser Combined With Topical Plant-Derived Exosomes Versus Non-Cross-Linked Hyaluronic Acid for Atrophic Acne Scars

Brief Summary

* Fractional CO₂ laser combined with topical exosomes and non-cross-linked hyaluronic acid both improve atrophic acne scars, but direct comparative evidence between these adjunctive therapies has been limited. * Adding topical exosomes via laser-assisted drug delivery may enhance scar remodeling and skin elasticity compared with HA, whereas HA provides superior hydration, supporting individualized treatment selection based on therapeutic goals. These findings are preliminary and require confirmation in larger studies.