The OXY-VENT Study

Brief Summary

Adequate ventilation during cardiopulmonary resuscitation is essential to maintain oxygenated blood supply to vital organs, yet achieving guideline-adherent synchronous ventilation (two breaths per pause after 30 compressions, with sufficient expiratory tidal volume) remains difficult in practice. In the prehospital setting, ventilation is delivered manually by resuscitator bag without measurement or feedback, and thoracic impedance data suggest that in 40-60% of ventilation pauses no ventilation is detected, with a dose-dependent association between successful ventilation and ROSC, survival, and neurological outcome in post-hoc analyses. Visible chest rise, the current clinical guide, correlates poorly with delivered tidal volume. Real-time ventilation feedback devices (VFDs) have improved ventilation quality in manikin studies, but an ILCOR scoping review found only few, mostly observational or before-after, clinical studies and called for prospective evaluation. We therefore hypothesize that real-time, objective feedback on tidal volume and leakage improves guideline adherence compared with standard, unguided ventilation, in a randomized trial in the setting of a supraglottic airway and synchronous ventilation.