Safety and Efficacy Study of Absorbable Tacrolimus Lacrimal Canalicular Plug for Dry Eye

Brief Summary

The goal of this clinical trial is to test if a new dissolvable tacrolimus plug placed in the tear duct is safe and to see how well it works for adults with moderate to severe dry eye. The main questions it aims to answer are: Is the dissolvable tacrolimus plug safe for the eyes? How well does the plug work to improve dry eye? Participants will be divided into three groups: Two groups will receive the dissolvable tacrolimus plug inserted into their tear duct (in two slightly different sizes). One comparison group will receive an already approved dissolvable plug (Dissolvable VisiPlug). All participants will use a standard lubricating eye drop four times a day in both eyes. All participants will attend follow-up visits for 24 weeks so doctors can check their eye health and any side effects.