Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)

Brief Summary

This study will evaluate whether temporal interference (TI) stimulation, added to usual clinical treatment, improves symptoms of schizophrenia and is safe and tolerable. Approximately 100 adults aged 18 to 60 years with schizophrenia will be randomly assigned in equal numbers to active TI or sham TI. Participants and researchers assessing treatment outcomes will not know which treatment has been assigned. Participants will continue usual clinical treatment and receive two 30-minute stimulation sessions daily for 14 consecutive days, for a total of 28 sessions. Symptoms will be assessed before treatment and on Days 7, 15, and 45. Magnetic resonance imaging (MRI) scans will be obtained before treatment and on Day 15. Side effects will be monitored throughout participation. The main question is whether active TI produces a greater improvement in overall schizophrenia symptoms from baseline to Day 15 than sham TI. The study will also assess symptom improvement at other time points, changes in other symptoms, treatment completion, safety, and changes in brain imaging measures.